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Historically, hyoscine was combined with opioids such as morphine or oxycodone from the late 19th century until the 1960s to induce a “twilight sleep” for women in labor. This combination provided profound analgesia, sufficient for use as a form of anesthesia at higher doses. Notably, a mixture of hyoscine, oxycodone (marketed as Eukodal), and ephedrine was sold by Merck under the names SEE (derived from the German initials of the components) and Scophedal starting...