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Raw mushrooms and raw mycelium may pose health hazards from harmful pathogens and heat-sensitive toxins—potentially causing red blood cell damage, gastrointestinal irritation, and allergic reactions, such as skin rashes.” – Dr. Paul Samets Another mushroom expert, Dr. Andrew Weil, in an article on his website, noted that “mushrooms have very tough cell walls and are essentially indigestible if you don’t cook them.